Most GIST are characterised by mutations in the gene PDGFRA or KIT. A small subset of GIST lacks these changes and is as an alternative characterized by deficiency in the gene succinate dehydrogenase .About 5-7% of GIST instances are SDH-deficient. Patients with SDH-deficient GIST are at the next danger for creating pulmonary chondromas and paragangliomas . Since 2008, the NIH has hosted a yearly clinic for patients with GIST that lack PDGFRA or KIT mutations. These clinics have contributed considerably to the understanding of GIST. Events are hosted across the nation and internationally to coach the neighborhood about GIST and provide support for GIST patients.

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